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. 2021 Dec 2;9:rbab072. doi: 10.1093/rb/rbab072

Table 2.

Comparison of the motor function recovery after SCI by using different drugs

Drugs Animal models Motor function recovery Other therapeutic effects Mechanisms Ref.
Valproic acid Traumatic SCI rat model Improve significantly Inhibits the NF-kB p65 transcriptional activity and weakens the microglia-mediated central inflammatory response Induces inflammation via STAT1 and NF-κB pathway-dependent of HDAC3 [39]
Resveratrol Traumatic SCI rat model Improve significantly Enhances autophagy Activates autophagy and inhibits apoptosis mediated by the SIRT1/AMPK signaling pathway [40]
Melatonin Traumatic SCI rat model Improve significantly Enhances autophagy Suppress inflammation and apoptosis [41]
Hepatocyte growth factor Traumatic SCI rat model Improve significantly Enhances angiogenesis around the lesion epicenter Promotes neuron and oligodendrocyte survival, angiogenesis, axonal regrowth, and functional recovery [42]
Zonisamide-loaded triblock copolymer nano micelles Spinal cord hemi-cut rat model Improve significantly Inhibits oxidative stress Plays a neuron-protective role by the antioxidative effect [43]
BRB-AuNCs Traumatic SCI rat model Motor function is significantly improved or even better recovery effect from the 7th day Promotes the polarization of M1 phenotype macrophages/microglia to M2 phenotype Triggers inflammation based on modulation of M1/M2 macrophage and reduction of apoptosis Current work