Valproic acid |
Traumatic SCI rat model |
Improve significantly |
Inhibits the NF-kB p65 transcriptional activity and weakens the microglia-mediated central inflammatory response |
Induces inflammation via STAT1 and NF-κB pathway-dependent of HDAC3 |
[39] |
Resveratrol |
Traumatic SCI rat model |
Improve significantly |
Enhances autophagy |
Activates autophagy and inhibits apoptosis mediated by the SIRT1/AMPK signaling pathway |
[40] |
Melatonin |
Traumatic SCI rat model |
Improve significantly |
Enhances autophagy |
Suppress inflammation and apoptosis |
[41] |
Hepatocyte growth factor |
Traumatic SCI rat model |
Improve significantly |
Enhances angiogenesis around the lesion epicenter |
Promotes neuron and oligodendrocyte survival, angiogenesis, axonal regrowth, and functional recovery |
[42] |
Zonisamide-loaded triblock copolymer nano micelles |
Spinal cord hemi-cut rat model |
Improve significantly |
Inhibits oxidative stress |
Plays a neuron-protective role by the antioxidative effect |
[43] |
BRB-AuNCs |
Traumatic SCI rat model |
Motor function is significantly improved or even better recovery effect from the 7th day |
Promotes the polarization of M1 phenotype macrophages/microglia to M2 phenotype |
Triggers inflammation based on modulation of M1/M2 macrophage and reduction of apoptosis |
Current work |