TABLE 4A.
Performance of HPV testing, conventional Pap smear, or Siriraj liquid‐based cytology to detect CIN2 or worse histology in women living with HIV‐1
| Test | CIN2 or worse Histology | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | LR+ (95% CI) | LR− (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| Yes | No | Total | |||||||
| CareHPV positive | 38 | 184 | 222 | 80.8% (67.4–89.5) | 68.5% (64.6–72.1) | 17.1% (12.7–22.6) | 97.8% (95.8–98.8) | 2.6 (2.1–3.1) | 0.3 (0.1–0.5) |
| CareHPV negative | 9 | 400 | 409 | ||||||
| HPV‐16 positive | 12 | 45 | 57 | 25.2% (15.2–39.5) | 92.2% (89.8–94.2) | 21.05% (12.4–33.2) | 93.9% (91.6–95.5) | 3 (1.8–5.8) | 0.8 (0.7–0.9) |
| HPV‐16 negative | 35 | 539 | 574 | ||||||
| ASC‐US or worse | 29 | 201 | 230 | 61.7% (47.4–74.2) | 65.5% (61.6–69.3) | 12.6% (9–17.6) | 95.5% (93–97.1) | 1.8 (1.4–2.3) | 0.6 (0.4–0.8) |
| Negative cytology (conventional Pap smear) | 18 | 383 | 401 | ||||||
| ASC‐US or worse | 37 | 180 | 414 | 78.7% (65–88) | 69.2% (65.5–73) | 17.1% (12.6–22.6) | 97.6% (95.6–98.6) | 2.6 (2.1–3.1) | 0.3 (0.1–0.5) |
| Negative cytology (Siriraj liquid based) | 10 | 404 | 217 | ||||||
Abbreviations: ASC‐US, Atypical squamous cells of undetermined significance or low‐grade squamous intraepithelial lesion or high‐grade squamous intraepithelial lesion or invasive cervical cancer; HIV‐1, human immunodeficiency virus‐1; HPV, human papillomavirus; LR−, negative likelihood ratio; LR+, positive likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.