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IHC staining for a nonenhancing region of predicted hypercellularity outside of contrast enhancement (a 64-year-old man diagnosed with GBM). The ROI corresponds to an actual region of hypercellularity seen on H&E staining as well as portions of high MIB-1 index and CD31 positivity. These molecular features indicate that this CPM-identified region contains active, proliferating tumor beyond the contrast-enhancing region. CPM indicates cellularity prediction map.
