Fig. 3.

Schematic of SPACE-peptide decorated cationic ethosomes for transdermal siRNA delivery (A). Skin permeability of peptide system under various conditions (B). Internalization of model drug by SPACE peptide after 30 min (C) and 120 min (D) incubation time. FITC internalization after 120-min incubation with various concentrations (E). Cell toxicity of SPACE peptide with 1 mg (open bar) and 10 mg (close bar) with keratinocytes for different time periods (F). The figure was

reproduced from ref. [65]. Copyright Elsevier 2014