Fig. 9.

Transdermal miRNA-based gene therapy. Schematic of miRNA-21 mimic BA-PEI nano-carrier for wound healing (A) and effect of miRNA-21 in wound healing (B). The figure was reproduced from [191].

Copyright Theranostic publication. MNs functionalized with be spoke peptide nucleic acid probe with covalently bound to alginate hydrogel via photo-cleavable linker (C). Protocol for MN-based sampling of target biomarker and purification to remove the non-target sequence (D). The figure was reproduced from ref. [192]. Copyright ACS publications 2019. Schematic of transdermal delivery of pDNA encoding miRNA-221 inhibitor gene by NPs for skin cancer treatment (E–H). The figure was reproduced from ref. [27]. Copyright ACS publication 2017. The miRNA-1331 delivered by ultrasound with low frequency suppressed the tumor growth and improved the survival rate. Tumor images after therapy (I), tumor growth during therapy (J), Survival rate with scramble-miRNA-MB (K), and survival rate with low frequency ultrasound (L). The figure was reproduced from ref. [193]. Copyright Wiley VCH 2016