Table 1.

Clinical presentation and duration of the disease

#	Age (y)	Sex	Clinical features	Past medical history	BMI on admission	Pulmonary superinfection	Invasive ventilation	Prone positioning	vvECMO	Hepatic failure	RRT	Sepsis	Catecholamine therapy	Hospital stay (d)	ICU stay (d)
1	77	m	Hyperactive delirium	aHT, CAD, obesity	34	+	+	+	–	–	+	+	+	81	81
2	75	m	Hyperactive delirium, seizures	aHT, AF, pulmonary embolism	25	–	–	–	–	–	–	–	+	38	37
3	62	m	Hypoactive delirium	aHT, DM2, smoking, obesity	30	+	+	+	–	–	+	+	+	76	73
4	73	m	Hypoactive delirium	myasthenia gravis	22	+	+	+	–	–	+	+	+	58	57
5	75	m	Hypoactive delirium	aHT, DM2, MI, aortic valve replacement	28	+	+	+	–	–	-	+	+	54	50
6	74	m	Hyperactive delirium, seizures, myoclonia	aHT, AF, renal transplant, obesity	32	+	+	–	–	+	+	+	+	195	64
7	52	f	Hypoactive delirium	aHT	27	+	+	–	–	–	+	+	+	55	55
8	43	m	Hyperactive delirium	obesity	31	+	+	+	+	–	–	+	+	103	100
9	49	m	Hyperactive delirium	aHT, DM2, sarcoidosis, obesity	30	+	+	+	+	+	+	+	+	102	99
10	59	f	Hypoactive delirium, myoclonia	aHT, DM2, obesity	34	+	+	+	–	+	+	+	+	Unknown	160
11	55	m	Hypoactive delirium	aHT, renal failure with RRT	22	+	+	+	–	+	+	+	+	57	53
12	72	m	Hypoactive delirium	aHT, CAD, MI	26	+	+	+	–	+	+	+	+	Unknown	33
													Median	67	60.5

Clinical features (pulmonary superinfection, invasive ventilation, proning, vvECMO, hepatic failure, RRT, sepsis, catecholamine therapy) are listed as “+” if they occurred at any time during the ICU stay. The term “delirium” is used in this manuscript to describe the clinical presentation of acute encephalopathy[2]. Before IVIg treatment, other sources of encephalopathy such as sepsis or hepatic failure were excluded at the time of clinical presentation of delirium, see exclusion criteria. For patients #10 and #12, the total duration of hospital stay could not be determined due to missing information about previous treatments in other hospitals. While 11 patients had at least one known cardiovascular risk factor, patient #4, who presented with known myasthenia gravis, did not. Patient #9 additionally suffered from stage II pulmonary sarcoidosis. Overall, most patients were severely affected by multiple complications (e.g., sepsis in 11, need for invasive ventilation in 11, renal failure with need of replacement therapy in nine, vvECMO in two patients)

− no, +  yes, AF atrial fibrillation, aHT arterial hypertension, BMI body mass index, CAD coronary artery disease, d days, DM2 diabetes mellitus type 2, f female, ICU intensive care unit, m male, MI myocardial infarction, RRT renal replacement therapy, vvECMO veno-venous extracorporeal membrane oxygenation, y years