Fig. 4. Functional analysis of up- and down-regulated proteins. (A) Top 10 proteins, which are up-regulated (red bars) and down-regulated (blue bars) in response to cGAMP. (B) Top 10 proteins, which are up-regulated (red bars) and down-regulated (blue bars) in response to c-di-GMP. Data were plotted using origin. These were (i) exclusively found in cGAMP treatment: (Lmf1, Prkcd, Uap1, Slc12a7, Capn1, Gpn3, Ddx5, Rpp25l, Ncoa5, Tubgcp3, mKIAA0357, Kdelc2, Eif1ad, C330007P06Rik, Eef1a1, Clec12a, Wwp2, Aim1, H2-T24, M3a,H2-M3, MHC class I, H-2M3, Snapin, Apol9a, Trafd1, Xaf1, H2-T23, Ncapg2, Micu2, Slc39a11, Tmem41b, Ppp2r5e, Tlr3, Pgam2, B2m, A730035I17Rik, Parp3, Gca, Rnf40, Nat2, Tc2n, Camlg, Timm10, Pgm2, D6Wsu163e, Heatr6, Sp1, Chtf18, Phip, Vps33a, Ptpro,PTPphi, Pcdh15, Arfgef3, Tbc1d23, Cecr5, Adck1, Tmem176b, Chrna3, Cwc25, Morf4l2, Asun,Mpa2l, Gbp10, Gbp6, Gbp8, Gbp4, Ogfod1, Stard3, Fam188a, Scyl2, Arhgap27, Crot, Ascc1, Anln, Hspa4l, Rasal2, Dab2ip, Dst, Tacc1, Tacc2, Tbcc,Nptn, Stam2, Mtmr3, Micu1); (ii) exclusively found in c-di-GMP treatment: (Reep5, Stim1, Lpcat4, Itgav, Arih2, Atp2c1, Ddx52, Clec4n, Clec6a, Clcn3, Irf2bp1, Coq9, Uxt, Mmtag2, Samsn1, Srd5a3, Naa35, Emilin2, Ranbp9, Ptgs2, Lpl, Snrpb2, Chid1, Cxcl10, C330027C09Rik;Kiaa1524, Igsf8, Dhps, Psmb10, Rbm34, Pmf1, Spryd7, H2-T23, Ccdc53, COX17, Fam20c, Parp10, Pdcd4, 9230104M06Rik, Crybg3, Bola2, LOC72520, Fam134b, Tmx4, Slc39a11, Sil1, Kif20b, Plau, Haus6;mKIAA1574, Ireb2, Mapk9, Anapc7, Dhx9, Zwint, Trim56, Ccbl2, Acox1, Agpat3, Clpb, Plch1, Mkln1, Rprd1a, Actbl2, Mtm1, Extl2, Abcb11, Mbnl1, Mbnl2, Bicd2, LRWD1, Lrwd1, Kif3a, Fech, Brcc3, Ttn, Exoc1, Sptan1, Hsdl2, Kif21b, Adam15, Tbc1d1, Smek2, Aven, Clptm1l, Itpr3, Thoc3, 10-Sep, Kif13b, Stard9, Kif1c, Kif16b, Kif13a, Naa30, Cd200r1, Las1l, Elovl1, Tgm2); (iii) exclusively found in control group: (Zfp706, gag, Prpf4b, Rras2, Nelfa, Ergic3, Orc5, Xpnpep3, Cx3cr1, Pom121, Abhd6, Ptpn2, Cryzl1, Rnaseh2b, Med22, Ca5b, Kank2, Ppil4, Ankrd44, Guf1, Pkp2, Setd1a, Rtfdc1, Zwilch, D2hgdh, Rsbn1, Rin2, Fam105a, Irf8, Nagk, Rasgrp3, Fam104a, Polr2h, Dph2, Mtpap, Anapc13, Wdr70, Nfatc1, Nubp2, Tbl1x, Sumf1, Cnnm3, Usp9x, L2hgdh, Ankle2, Pus7l, Mon2, Rps6ka4, Nkiras2, 1810009N02Rik, Rgs19, Tti1, Synrg, Lipt2, Mpi,Iscu,Uprt, Rad18, 0610011F06Rik, Arfgap3, Rpusd2, Wbp4, Runx1, Tarbp2, mKIAA0971, Sestd1, Mlycd, Ptpmt1, Hirip3, Znf512, Vps51, Rab3d, Atp6v1g1, Arl15, Rsbn1l, Rpf1, Wdr48, Slc7a5, Arpc5l, Ccs, Plxna2, Akr1b10, Mfsd1, Ccdc88b, Fmr1, Lnp, Slc7a6, Fdx1l, Tbc1d10b, Ranbp10, Klhl9, Napsa, Zfand5, Gcc2, Morc2b, Ints1, Dnase2a, Eif4ebp2, Grcc10, Ccz1, Mtss1, Tfe3, Rab3gap2, Ak1, Tfam, Flad1, Glul, Fam107b, Flcn, Mtfr1l, Maea, Acsf3, Nif3l1, L7rn6, Slc17a5, Snap47, Gemin5, Uqcc1, Mfn2, 5430435G22Rik, Pctk2, Exoc5, Fam206a, Rars2, Irak4, Thtpa, Malt1, Mcat, Adcy7, Rpusd3, Wbscr16, Cdkn1b, Ammecr1l, Tdp1, Ccdc91, Abcc4, uncharacterized protein C19orf52 homolog, Gm21992, Ctu2, Npm3, Ehmt1, Gyg, Wdr74, Pfkm, Mrpl4, Ptpn23, Ddi2, Dph5, Mpc1, uncharacterized protein C4orf3 homolog, Zmynd8, Cbwd1, Eri3, Cerk). Also see ESI set 1, Table S5.†.