Fig. 1. Effects of GE on the expressions of BSEP in vivo and in vitro. Effect of GE (150 mg kg−1) on mRNA (A) and protein (C) expression of BSEP in ANIT-induced cholestatic mice. (B) Effect of GE on mRNA expression of BSEP in HepG2 cells. GW4064 (5 μM) was used as positive control. The mRNA levels were standardized to GAPDH. In west blotting analysis, specific band intensity was quantified, normalized to GAPDH. Data are the mean ± S.E.M. (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle or DMSO, ##P < 0.01 vs. ANIT group.
