Figure 3.

Elevated T‐follicular helper (Tfh) cell response and germinal center reaction in TREX1 deficiency. Levels of Tfh cells (CD4⁺CXCR5⁺PD1⁺) and GL7^hiCXCR5⁺B220⁺ B‐cells in (A) TREX1 D18N and (B) TREX1 KO female mice analyzed by flow cytometry. Data presented as mean ± SEM relative to WT mice (normalized absolute numbers) and a total of four to five mice per group over three independent experiments, with the dots representing individual mice. *p < 0.01, **p < 0.001, ***p < 0.0001 as calculated by two‐tailed unpaired Student's t‐test. Also see Supporting information Fig. S3 for data in percentages.