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. Author manuscript; available in PMC: 2023 Mar 18.
Published in final edited form as: J Org Chem. 2022 Mar 7;87(6):4195–4203. doi: 10.1021/acs.joc.1c03029

Table 2.

ITC binding data of MINP(1a–f) for substrate 6.a

entry MINP guest Ka
(× 104 M−1)		 ΔH (kcal/mol) ΔS (cal/mol/K) ΔG (kcal/mol)
1 MINP(1a) 6 4.60 ± 0.59 −0.38 ± 0.01 20.1 −6.37
2 MINP(1b) 6 2.45 ± 0.36 −0.82 ± 0.04 17.3 −5.98
3 MINP(1c) 6 2.11 ± 0.40 −0.55 ± 0.02 17.9 −5.89
4 MINP(1d) 6 2.19 ± 0.46 −1.15 ± 0.06 16.0 −5.92
5 MINP(1e) 6 1.69 ± 0.45 −1.64 ± 0.08 13.8 −5.75
6 MINP(1f) 6 1.58 ± 0.14 −0.51 ± 0.04 17.5 −5.73
a

Titrations were carried out in 10 mM citrate buffer pH = 5.0 at 298K, in the presence of 1 equivalent of 1-pyrenecarboxylic acid (5) in the solution. The errors between the runs were <10%.