TABLE 3.

Classification Criteria for Serpiginous Choroiditis

Criteria

1. Paucifocal or multifocal choroiditis with an ameboid or serpentine shapea

AND

2. Characteristic imaging

a. Fluorescein angiogram with early diffuse hypofluorescent lesions and late hyperfluorescent lesion borders OR

b. Fundus autofluorescence with hypo-autofluorescent lesions with hyper-autofluorescent borders

AND

3. Absent-to-minimal anterior chamber and vitreous inflammation

Exclusions

1. Positive serologic test for syphilis using a treponemal test

2. Evidence of sarcoidosis (either bilateral hilar adenopathy on chest imaging or tissue biopsy demonstrating noncaseating granulomata)

3. Evidence of infection with Mycobacterium tuberculosis, either

a. Histologically or microbiologically confirmed infection with M. tuberculosisb OR

b. Positive interferon-γ release assayc OR

c. Positive tuberculin skin testd

^aLesions do not need to be contiguous with the optic disc.

^bFor example, biopsy-, fluorochrome stain–, culture-, or polymerase chain reaction–based assay.

^cFor example, QuantiFERON gold or T-spot.

^dFor example, purified protein derivative; a positive result should be > 10 mm induration.