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. 2001 Dec;45(12):3669–3671. doi: 10.1128/AAC.45.12.3669-3671.2001

TABLE 1.

CMV load and UL97 mutations in leukocytes of allogeneic blood transplant recipients with persistent or recurrent antigenemia despite GCV preemptive therapy

Patient No. of days after transplantation (viremia episode) Cumulative no. of days of GCV treatment (route) Antiviral regimen at time of sampling (route) Viral load in PMNL by:
UL97 mutation detectedc
pp65 antigenemia assaya PCRb
1 98 (first) 14 (i.v.), 35 (p.o.d) GCV (p.o.) 0 1.63 × 103 None
2 63 (first) 14 (i.v.) GCV (i.v.) 0 1.13 × 103 None
3 91 (second) 14 (i.v.), 14 (p.o.) None 8 1.17 × 104 None
4 77 (second) 14 (i.v.), 14 (p.o.) None 1 2.51 × 102 None
5 84 (first) 14 (i.v.), 12 (p.o.) GCV (p.o.) 0 2.90 × 103 None
6 84 (second) 14 (i.v.), 14 (p.o.) None 0 8.56 × 102 None
7 77 (first) 14 (i.v.), 7 (p.o.) GCV (p.o.) 0 8.31 × 102 None
8 77 (second) 28 (i.v.), 14 (p.o.) None 18 1.65 × 104 None
91 (second) 42 (i.v.), 14 (p.o.) GCV (i.v.) 0 8.80 × 102 None
9 70 (second) 14 (i.v.), 14 (p.o.) None 1 1.88 × 104 S510
77 (second) 21 (i.v.), 14 (p.o.) GCV (i.v.) 2 5.64 × 104 S510
10 70 (first) 14 (i.v.), 14 (p.o.) GCV (p.o.) 0 4.59 × 102 None
84 (second) 14 (i.v.), 14 (p.o.) None 4 1.72 × 104 None
a

CMV pp65 antigenemia assay results are expressed as the numbers of positive cells per 2 × 105 PMNL. 

b

COBAS AMPLICOR CMV MONITOR test (PCR) results are expressed as the numbers of CMV copies per 4 × 106 PMNL. 

c

A rapid screening assay detected UL97 mutations Q520, S595, and F595 as well as other mutations at codons 460 and 594. The S510 mutation has a restriction pattern similar to that of a Q520 mutation. 

d

p.o., per os.