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. 2022 Apr 22;7(8):e156048. doi: 10.1172/jci.insight.156048

Figure 1. Low-resolution clustering of T cells from lupus-prone mice.

Figure 1

(A) Schematic of experimental design encompassing tissue source, sorting algorithm, marking with HTOs, number of mice used in each experimental cohort, and a description of downstream analytic techniques. (B) UMAP of T cells from mice in Main-Seq, outlining 14 clusters. (C) HTO-based assignment of cell source was mapped onto the UMAP. MRL/lpr, MRL.Faslpr; B6, C57BL/6; UMAP, uniform manifold approximation and projection; TF, transcription factor.