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. 2022 Apr 22;7(8):e156070. doi: 10.1172/jci.insight.156070

Figure 4. Tissue eccDNA size profiling of wild-type, Dnase1−/−, and Dnase1l3−/− mice using the tagmentation-based method.

Figure 4

Liver eccDNA was analyzed in (A) 5 wild-type, (B) 5 Dnase1−/−, and (C) 5 Dnase1l3−/− mice; buffy coat eccDNA was analyzed in (D) 6 wild-type, (E) 4 Dnase1−/−, and (F) 5 Dnase1l3−/− mice. EccDNA identified in each tissue type was pooled for each genotype of mice and size profiled. The AUC ratios were compared among the 3 groups of mice for both (G) the liver and (H) buffy coat. Kruskal-Wallis test detected no statistically significant difference among the 3 groups of mice in either the liver (P = 0.45) or buffy coat (P = 0.10).