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. 2022 Apr 22;7(8):e151509. doi: 10.1172/jci.insight.151509

Figure 6. Absence of Adamts2 affects lymphatic formation in postnatal day 6 mice.

Figure 6

Skin sections were stained using antibodies for LYVE1 (green) and CD31 (red). Scale bar: 200 μm. (A) Because of coexpression of LYVE1 and CD31, lymphatics appear as yellow structures, mainly in the upper dermis and in close association with the bulge region of the hair follicle (18). LYVE1-positive cells identified in the lower dermis and in the adipose tissue were mainly macrophages (Supplemental Figure 6). (B) Computerized quantification of LYVE1 staining in the upper dermis. As compared with WT mice, fewer lymphatics were observed in TS2–/– and TS2–/–TS14–/– mice. E, epidermis (white arrows); UD, upper dermis; LD, lower dermis. Statistical analyses were performed using Kruskal-Wallis test followed by Holm-Šidák post hoc test for multiple comparisons. *P < 0.05; **P < 0.01; ***P < 0.001.