Table 2. Statistical separation of UMAP clusters between real datasets.

	Phenotype A	Phenotype B	Phenotype C	Phenotype D	Phenotype E
Phenotype A	1	0.02	0.001	0.001	0.001
Phenotype B	-	1	0.02	0.001	0.001
Phenotype C	-	-	1	0.001	0.001
Phenotype D	-	-	-	1	0.001
Phenotype E	-	-	-	-	1

Maximum p-values calculated by the ClusterSignificance permutation package in R [35]. p-values are given after at least 1000 permutations. Phenotype codes described in the methods, Table 1.