Table 2. Outcomes of hospitalized severe or critical COVID-19 patients by vaccine status.
| Total n = 349 | No vaccine n = 202 | Two Vaccines n = 122 | Booster n = 25 | P | |
|---|---|---|---|---|---|
| No. (%) | No. (%) | No. (%) | No. (%) | ||
| COVID-19 worse severity: ª | |||||
| Severe | 243 (70) | 131 (65) | 90 (74) | 22 (88) | 0.028 |
| Critical | 106 (30) | 71 (35) | 32 (26) | 3 (12) | |
| Maximal oxygen support needed: b | |||||
| Nasal cannula | 179 (52) | 91 (45) | 70 (58) | 18 (72) | 0.004 |
| Oxygen mask | 64 (18) | 40 (20) | 20 (16.5) | 4 (16) | |
| Non-invasive | 57 (16) | 39 (19) | 17 (14) | 1 (4) | |
| Intubation | 47 (13.5) | 31 (15) | 14 (12) | 2 (8) | |
| Death | 70 (20) | 40 (20) | 26 (21) | 4 (16) | 0.825 |
| ICU admission | 36 (10) | 29 (14) | 7 (6) | 0 | 0.010 |
| Hospital duration, mean, days | 8.05± 8.47 | 8.7± 9.5 | 7.2± 6.9 | 6.4± 5.2 | 0.185 |
| Extra–pulmonaryc | 37 (11) | 18 (9) | 16 (13) | 3 (12) | 0.479 |
| AKId | 88 (25) | 50 (25) | 32 (26) | 6 (24) | 0.947 |
| Other proven infectione | 54 (15.5) | 25 (12) | 24 (20) | 5 (20) | 0.172 |
Abbreviations: COVID-19, coronavirus disease 2019; ICU, intensive care unit; AKI, acute kidney injury.
ª Severity of illness was determined according to the National Institutes of Health and Israel Ministry of Health definitions.
b Oxygen mask include the need of a low flow mask (venturi mask) or a reservoir mask; Non-invasive include the need of continuous positive airway pressure (CPAP) or high-flow nasal cannula (HFNC).
c Cardiovascular, neurological, and hematological complications attributed to COVID-19 effect.
d Acute kidney injury diagnosed as an increase in serum creatinine by ≥0.3 milligrams per deciliter (mg/dl) within 48 hours or an increase in serum creatinine to ≥1.5 times baseline.
e Non COVID-19 infection is defined by symptoms not attributed to covid-19 with a relevant positive culture.