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Summary of DLTs
| Dose Level | Prexasertib Dose (mg/m2) | Part | No. of Patients Entered | No. of Patients Evaluable | No. of Patients with Cycle 1 DLTs | No. of Patients with Later-Cycle DLTs |
|---|---|---|---|---|---|---|
| 1 | 80 | A | 6 | 6 | 0 | 0 |
| 2 | 100 | A | 6 | 5 | 0 | 0 |
| 3 | 125 | A | 6 | 4 | 0 | 0 |
| 4 | 150 | A | 6 | 5 | 0 | 0 |
| 4 | 150 | PK | 6 | 5 | 0 | 0 |
Abbreviations: A= dose-escalation cohort; DLT= dose-limiting toxicity; No.= number; PK= Pharmacokinetic expansion cohort
