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. 2022 May 9;7(9):e150871. doi: 10.1172/jci.insight.150871

Figure 6. BRD4 mediates the profibrotic effect of BETs in dcSSc fibroblasts.

Figure 6

(A) BRD2 knockdown in dcSSc fibroblasts led to upregulation of COL1A1, and BRD3 knockdown resulted in downregulation of TIMP3. Knockdown of BRD4 resulted in downregulation of COL1A1, ACTA2, TGFB, CTGF, and MMP1. n = 5–6 patients. (B) BRD4 knockdown significantly inhibited gel contraction in dcSSc fibroblasts, whereas BRD2 or BRD3 knockdown had minimal effect on gel contraction. n = 4–5 patients. Results are expressed as mean ± SD and P < 0.05 was considered significant. (A and B) Significance was determined by unpaired 2-tailed t test or Mann-Whitney U test.