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. 2022 May 9;7(9):e152765. doi: 10.1172/jci.insight.152765

Figure 1. IFN-κ is important for normal tissue repair.

Figure 1

(A) Total wound keratinocytes were isolated from day 0, 1, 3, and 5 wounds, and Infk expression was examined via qPCR. n = 3–5 mice per group, repeated 2 times in triplicate. (B) The 4 mm punch biopsy wounds were created on WT (Ifnk+/+) and IFN-κ–KO (Ifnk–/–) mice. The change in wound area was recorded daily and analyzed with ImageJ software (2 wounds per mouse, n = 5 mice per group). (C) Representative photographs of the wounds were taken on day 5. (D) Wound diameter at day 3 for Ifnk+/+ and Ifnk–/–; n = 4 per group. Trichrome staining representation is shown. (E) Wounds isolated from WT and IFN-κ–KO mice on day 3, n = 3 per group. Gene expression of inflammatory cytokines Tnf, Il1b, and Il12 was measured via qPCR. Data were analyzed for variances, and 2-tailed Student’s t test or 1-way ANOVA was performed. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. Data are presented as mean ± SEM.