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. 2022 May 5;23(1):378–392. doi: 10.1080/15384047.2022.2041961

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — CAFs-derived EVs transport miR-331-3p to promote the proliferation, migration and invasion of PC cells by suppressing SCARA5.

A. The expression of SCARA5 in SW1990 and PANC-1 cells overexpressing SCARA5 determined by RT-qPCR. SW1990 and PANC-1 cells were treated with oe-SCARA5 + DMSO, oe-SCARA5 + EVs-NC + DMSO, oe-SCARA5 + EVs-miR-331-3p + DMSO or oe-SCARA5 + EVs-miR-331-3p + VS6063. B. The expression of miR-331-3p and SCARA5 in SW1990 and PANC-1 cells determined by RT-qPCR. C. Proliferation of SW1990 and PANC-1 cells measured by CCK-8 assay. D. Migration and invasion of SW1990 and PANC-1 cells measured by Transwell assay. E. Expression of MMP-2 and MMP-9 in SW1990 and PANC-1 cells determined by Western blot analysis. F. Expression of MMP-2 and MMP-9 in the supernatant of SW1990 and PANC-1 cells measured by ELISA. G. p-FAK/FAK ratio in SW1990 and PANC-1 cells determined by Western blot analysis. Experiments were repeated 3 times. ** indicates p < .01, *** indicates p < .001, and **** indicates p < .0001.