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. 2022 May 5;23(1):378–392. doi: 10.1080/15384047.2022.2041961

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — CAFs-derived EVs transport miR-331-3p to promote the tumorigenesis of PC in vivo.

A. Representative images showing xenografts in nude mice and tumor volume statistics. B. The graph of tumor weight. C. Expression of miR-331-3p and SCARA5 in mouse tumor tissues determined by RT-qPCR. D. Expression of proteins in FAK pathway in mouse tumor tissues determined by Western blot analysis. E, Representative images of Ki67 and p-FAK in mouse tumor tissues determined by immunohistochemistry. F, Quantitative analysis of panel E. G, Fluorescence probe detection of the cellular localization of miR-331-3p. ** indicates p < .01, *** indicates p < .001, and **** indicates p < .0001. n = 15 for mice in each group.