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. 2022 May 10;11:e73913. doi: 10.7554/eLife.73913

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© 2022, Demange et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 6. — The protein reactive species generated upon bioactivation modify several proteins including the essential 26 S proteasome subunit PSMD2, thereby triggering Ub-proteasome system (UPS) inhibition, ER-stress, activation of the Unfolded Protein Response (UPR) and cell death mediated by apoptosis. See Figure 6—figure supplement 1 for a graphical abstract depicting the main findings and techniques used.

Figure 6—figure supplement 1. — The protein reactive species generated upon bioactivation modify several proteins including the essential 26 S proteasome subunit PSMD2, thereby triggering Ub-proteasome system (UPS) inhibition, ER-stress, activation of the Unfolded Protein Response (UPR) and cell death mediated by apoptosis. See Figure 6—figure supplement 1 for a graphical abstract depicting the main findings and techniques used.