Figure 2.

Schematic domain organization of CAIX and CAXII. CAIX: The proteoglycan-like domain, PG (residues 53–111, pink); the catalytic domain, CA (residues 137–391, orange); the transmembrane segment, TM (residues) 415–433, yellow) and the intracellular C-terminal domain, CT (residues 434–459, blue)^8,10. CAXII is shorter in length than CAIX and lacks the PG. It consists of 4 distinct domains including a signal peptide (not shown here), N terminus extracellular CA domain (1–269), a TM domain (270–296), and a CT domain (297–325)^9,11. Created with BioRender.com