Table 3.
Baseline CCTA characteristics according to cholesterol efflux capacity distribution and HDL-C levels.
| SR-BI cholesterol efflux capacity |
ABCA1 cholesterol efflux capacity |
HDL-cholesterol |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| <25th (n 43) | 25–75th (n 90) | >75th (n 45) | p value | <25th (n 40) | 25–75th (n 90) | >75th (n 48) | p value | ≤ 50 mg/dL (n 124) |
> 50 mg/dL (n 54) |
p value |
|
| CCTA characteristics | |||||||||||
| Lumen stenosis > 70%, n (%) | 17 (39.5) | 38 (42.2) | 25 (55.6) | .243 | 18 (45) | 46 (51.1) | 16 (33.1) | .1354 | 57 (46) | 23 (42.6) | .677 |
| SSS, mean ± SD | 11.6 ± 6.4 | 11.5 ± 6.0 | 11.9 ± 5.1 | .93 | 12.3 ± 7.1 | 11.9 ± 5.8 | 10.5 ± 4.7 | .273 | 11.8 ± 6.0 | 11.2 ± 5.4 | .504 |
| SIS, mean ± SD | 7.6 ± 2.1 | 7.6 ± 2.0 | 7.6 ± 1.8 | .989 | 7.6 ± 2.0 | 7.7 ± 2.1 | 7.4 ± 1.6 | .627 | 7.6 ± 1.9 | 7.7 ± 2.0 | .826 |
| Leaman CT-adapted score, mean ± SD | 10.3 ± 4.0 | 10.8 ± 4.4 | 10.6 ± 3.9 | .831 | 10.6 ± 4.6 | 10.8 ± 4.0 | 10.2 ± 4.2 | .700 | 10.9 ± 4.1 | 10.0 ± 4.3 | .211 |
| RI > 1.4, n (%) | 30 (69.8) | 53 (58.9) | 21 (46.7) | .089 | 21 (52.5) | 57 (63.3) | 26 (54.2) | .401 | 76 (61.3) | 28 (51.9) | .240 |
| LAP, n (%) | 29 (67.4) | 56 (62.2) | 32 (71.1) | .569 | 25 (62.5) | 62 (68.9) | 30 (62.5) | .668 | 86 (69.3) | 31 (57.4) | .123 |
| NRS, n (%) | 14 (32.6) | 14 (23.5) | 11 (24.4) | .076 | 7 (17.5) | 26 (28.9) | 6 (12.5) | .064 | 34 (27.4) | 5 (9.3) | .007 |
| SC, n (%) | 19 (44.2) | 30 (33.3) | 19 (42.2) | .394 | 14 (35.0) | 33 (36.7) | 21 (43.7) | .641 | 47 (37.9) | 21 (38.9) | .901 |
| More than 2 HRF per type, n (%) | 13 (30.2) | 20 (22.2) | 15 (33.3) | .335 | 7 (17.5) | 29 (32.2) | 12 (25.0) | .204 | 36 (29.0) | 12 (22.2) | .347 |
| Pl Total Vol (mm3), median (IQR) | 204 (100–312) | 171 (103–277) | 170 (100–277) | .823 | 174 (93–290) | 180 (109–355) | 162.5 (100–260) | .510 | 180 (102–312) | 163.5 (101.5–266) | .328 |
| Pl Vol HU < 150 (mm3), median (IQR) | 45 (20–97) | 31.5 (5–70) | 29 (10.5–71.5) | .261 | 27 (5–84) | 40.5 (15–86) | 29 (7.5–70) | .346 | 40 (12.5–85.5) | 25.5 (3.9–64.4) | .066 |
| Pl Vol HU < 30 (mm3), median (IQR) | 3 (0–17) | 2 (0–7.4) | 2.6 (0–9.5) | .481 | 2 (0–10) | 3 (0–11) | 2 (0–5) | .470 | 3 (0–10) | 1 (0–5) | .086 |
| Plaque length (mm), median (IQR) | 46 (27–63) | 40.5 (27.8–56) | 46 (27.5–61) | .500 | 48 (32–63) | 45.5 (28.7–63) | 38.7 (24–50) | .041 | 43.5 (27–62) | 39.5 (28–53) | .306 |
| Pl Vol HU < 150/Plaque length | 28.4 (12.8–39.8) | 17.5 (6.6–30.2) | 20.3 (9.0–31.9) | .051 | 14.7 (4.8–35.1) | 22.4 (12.3–30.3) | 14.3 (7.2–37.9) | .457 | 22.7 (11.1–37.2) | 15 (6.6–27.4) | .062 |
| Pl Vol HU < 30/Plaque length | 0.10 (0–0.25) | 0.05 (0–0.2) | 0.04 (0–0.2) | .51 | 0.03 (0–0.23) | 0.06 (0–0.22) | 0.05 (0–0.19) | .638 | 0.07 (0–0.22) | 0.03 (0–0.15) | .130 |
| Myocardial mass, mean ± SD | 115.7 ± 26.6 | 119.1 ± 23.8 | 121.1 ± 31.0 | .630 | 115.6 ± 23.6 | 117.8 ± 24.5 | 123.1 ± 31.6 | .383 | 118.7 ± 25.7 | 119.0 ± 28.1 | .938 |
CCTA: coronary computed tomography angiography; SR–BI: scavenger receptor class B type I; ABCA1: ATP binding cassette transporter A1; HDL: high-density lipoproteins; SSS: segment stenosis score; SIS: segment involvement score; RI: Remodelling index; LAP: low attenuation plaque; NRS: napkin ring sing; SC: spotty calcification; HRF: high risk features; Pl Vol: plaque volume; IQR: interquartile range; SD: standard deviation.