Table 2.
Inhibition data for compounds found to be active against cultured Plasmodium falciparum.
| Molecule | KUID | IC50 Pf-apPOL (µM) | IC50 Pb-apPOL (µM) | IC50 Bb-apPOL (µM) | EC50 (µM) | EC50 + IPP (µM) |
|---|---|---|---|---|---|---|
| 1 | KU0263501 | 5.9 ± 0.9 | 7.1 ± 0.6 | 3.7 ± 0.2 | 8.6 ± 0.4 | 9.3 ± 0.5 |
| 21 | KU0036696 | 8 ± 1 | 9.7 ± 1.6 | 8 ± 2 | 3.1 ± 0.1 | 3.4 ± 0.1 |
| 27 | KU0260920 | 15 ± 1 | ND | ND | 10 ± 1 | 9 ± 1 |
| 31 | KU0007309 | 15 ± 1 | ND | 15 ± 5 | 8.9 ± 0.5 | 8.7 ± 0.6 |
| 34 | KU0241474 | 7.2 ± 0.9 | ND | ND | 11.3 ± 0.9 | 10.0 ± 0.7 |
| 55 | KU0177470 | 10 ± 2 | 51.9 ± 3.5 | 1.5 ± 1.0 | 3.5 ± 0.3 | 4.3 ± 0.2 |
| 94 | KU0261556 | 7.6 ± 0.6 | 13.9 ± 1.6 | 30 ± 3 | 4.6 ± 0.2 | 3.7 ± 0.5 |
| 95 | KU0001071 | 7.4 ± 0.4 | 8.6 ± 0.7 | 2.5 ± 0.2 | 7.5 ± 0.5 | 7.4 ± 0.4 |
| 98 | KU0271653 | 8 ± 2 | ND | ND | 16 ± 1 | 11 ± 1 |