In vitro phase I and reactive metabolites of DCB.

	MS scan	Most abundant fragment ions	Rt. (min)	Metabolic reaction
DCB	470	385, 319, 152, 124	33.5	Parent drug
DCB484	484	385, 319, 166, 144	39.5	α Oxidation at piperidine ring
DCB472	472	387, 321, 152, 124	32.2	Reduction at quinazoline ring
DCB486a	486	387, 166, 138	39.2	α Oxidation at piperidine ring and reduction at quinazoline ring
DCB486b	486	385, 319, 168	30.4	Hydroxylation at piperidine ring
DCB495	495	385, 319, 122	52.5	Cyano adduct
DCB362	362	332, 305	38.7	Methoxyl amine conjugate (oxime)