Fig. 2. Discrimination power of single chimerism values in CD33⁺ cells to predict impending or overt relapse.

Receiver operating characteristics (ROC) curves depicting the true positive rate (sensitivity) and false positive rate (1-specificity) of relapse prediction in acute myeloid leukemia patients after hematopoietic stem cell transplantation. Chimerism from (a) bone marrow and (b) blood samples were analyzed at the clinician’s discretion. The analysis includes chimerism values obtained from 30 days after transplantation to the day of clinical relapse or an equal length of time in the group that did not have a relapse. Youden’s index suggest a cutoff that makes a trade-off between sensitivity and specificity.