Table 3.
Relapse predicted by max recipient chimerism (%max) in samples taken before or at time of relapse.
| Univariable | Bone marrow (n = 141) | Blood (n = 119) | ||||
|---|---|---|---|---|---|---|
| P | OR | CI 95% | P | OR | CI 95% | |
| CD3 | 0.009 | 1.03 | 1.01–1.06 | 0.18 | 1.03 | 0.99–1.07 |
| CD19 | 0.003 | 1.03 | 1.01–1.05 | 0.70 | 1.01 | 0.95–1.06 |
| CD33 | 2.3 × 10−6 | 1.04 | 1.02–1.05 | 0.24 | 1.02 | 0.99–1.06 |
| CD34 | 3.3 × 10−6 | 1.03 | 1.02–1.04 | – | – | – |
| Multivariable | ||||||
| CD33 | 2.6 × 10−6 | 1.04 | 1.02–1.06 | 0.21 | 1.02 | 0.99–1.06 |
| Patient age | 0.82 | 1.00 | 0.97–1.04 | 0.95 | 1.00 | 0.97–1.03 |
| CR vs not | 0.23 | 0.41 | 0.09–1.89 | 0.05 | 0.28 | 0.07–1.06 |
| MAC vs RIC | 0.68 | 1.30 | 0.36–4.68 | 0.75 | 1.22 | 0.35–4.30 |
| Related vs not | 0.57 | 1.34 | 0.48–3.67 | 0.92 | 1.05 | 0.39–2.77 |
P values are from logistic regression analysis.
OR Odds ratio, CI Confidence interval, CR Complete remission before transplantation, MAC Myeloablative conditioning, RIC Reduced intensity conditioning, Related vs not HLA-identical sibling or haploidentical relative vs matched unrelated donor, n number of transplants.