Fig. 4. Characterization and bioinformatic analysis of differential glycoproteins isolated from DN and NDRD. Gene Ontology (GO) domain overview of differential proteins. The differential proteins of DN and NDRD were input into the three GO domains: biological process (A), cellular component (B), and molecular function (C) and the resultant terms associated with these terms are visualized as pie charts. Term names are located next to their position on the chart. (D and E) Protein interaction network generated and visualized with STRING 9.0 for differential proteins of DN or NDRD. The strength of the associations is represented by line thickness. Networks with three or more protein interactions are shown. Required confidence (score) of protein association was high confidence. Selected, functionally important protein core complexes and the proteins involved in same biochemical reaction are marked with red imaginary line.