Fig. 7.

β-OHB metabolisms were obscured under hypoxic conditions in cardiac myocytes. a Detected concentration of β-OHB in CMs cultured with β-OHB (0, 0.1, 1, 10, 20, 50 mM) at different concentrations under normoxia or hypoxia; b and c western blot of SLC16A1, BDH1, OXCT1, OXCT2, and ACTA1 which are β-OHB transporters and the key enzymes for ketone body metabolism in CMs cultured with 10 mM β-OHB under normoxia or hypoxia (n = 3 in each group); d ATP in CMs cultured with 10 mM β-OHB under normoxia or hypoxia (n = 8 in each group). Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001