Fig. 8.

KD exacerbated cardiac dysfunction in mice after MI surgery. a The level of β-OHB in plasma of model mice (n = 9–11 in each group); b triphenyl tetrazolium chloride staining in 4 weeks post-myocardial infarction (n = 8 in each group); c the infarct area detected by TTC staining was quantified to the left ventricular area; d, e, and f left ventricular ejection fraction (LVEF) and fractional shorting (FS) were measured by echocardiography (n = 8–10 in each group); g western blot of HIF-1α and GLUT1 analysis from myocardium of KD or CD mice after MI surgery (n = 6 in each group); h immunofluorescence imaging of GLUT1 in myocardium of KD or CD mice after MI surgery. Scale bars, 20 μm. Data are mean ± SEM. **P < 0.01