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. 2022 May 10;5:433. doi: 10.1038/s42003-022-03400-1

Fig. 2. HSV-1 and AdV cause cGAS release from the chromatin to the nuclear soluble fraction.

Fig. 2

a RAW 264.7 macrophages were infected with 1 MOI of HSV-1 McKrae for designated times, and then the subcellular fractions of cell lysates were blotted as indicated. The arrow indicates nuclear soluble cGAS after viral infection. STING: membrane marker; α-tubulin: cytosolic marker; H3: nuclear marker; ICP8: HSV-1 viral protein; HDAC2: nuclear marker. be RAW 264.7 macrophages were infected with 1 MOI of AdV (b), VACV (c), IAV (d) or VSV (e) for 16 h. The subcellular fractions were blotted as indicated. The arrow indicates nuclear soluble cGAS after viral infection.