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. 2022 Apr 8;29(5):961–971. doi: 10.1038/s41418-022-00996-z

Fig. 3. Regulation of DNA damage repair by TP53.

Fig. 3

Activated TP53 can transcriptionally upregulate an array of direct target genes involved in a range of DNA damage repair pathways, including base excision repair, non-homologous end joining, homologous recombination, nucleotide excision repair and mismatch repair. Thick arrows indicate the type of DNA damage repair pathway that is needed for the repair of a specific type of DNA lesion. The genes to the side of the arrows are genes that are upregulated by TP53 to orchestrate that particular damage repair pathway.