Table 1.
DNA repair genes that are directly regulated by TP53 and whose knock-out can promote spontaneous, UV-B- or γ-radiation induced tumour development in mice.
| Gene | DNA damage repair pathway | Gene knockout | Treatment | Outcome | Reference |
|---|---|---|---|---|---|
| Xpc | NER | −/− | UV-B Irradiation | Skin squamous cell carcinoma | [89] |
| Gadd45a | NER | −/− | Ionising Radiation | Lymphoma | [90] |
| Ddb2 | NER | −/− | UV-B Irradiation | Skin carcinoma | [96] |
| Mlh1 | MMR | −/− | – | Lymphoma and gastro-intestinal tumours | [100] |
| Msh2 | MMR | −/− | – | Colon carcinoma and lymphoid tumours | [97, 99] |