Skip to main content
. 2018 Nov 27;8(69):39611–39625. doi: 10.1039/c8ra08426b

In vitro anticandidal activity of compounds (6a–q) against Candida spp.

graphic file with name c8ra08426b-u2.jpg
Comp. R IC50 ± S.D (μg mL−1)
C. albicans C. glabrata C. tropicalis
6a H 118.7 ± 7.6 566.1 ± 9.4 184.1 ± 4.8
6b o-Cl 168.8 ± 3.4 266.5 ± 10.3 210.6 ± 13.3
6c o-F 100.7 ± 3.7 174.4 ± 3.1 24.8 ± 2.7
6d o-CH3 131.2 ± 4.3 357.7 ± 6.8 233.1 ± 6.9
6e o-OCH3 48.2 ± 3.2 29.4 ± 4.2 9.1 ± 2.7
6f o-NO2 700.8 ± 23.6 486.6 ± 18.5 520.7 ± 24.1
6g m-Cl 100.3 ± 4.0 278.1 ± 4.0 244.6 ± 2.0
6h m-F 134.8 ± 2.4 261.9 ± 13.3 175.2 ± 3.6
6i m-CH3 133.4 ± 4.2 244.8 ± 11.2 222.8 ± 18.7
6j m-OCH3 214.3 ± 11.0 453.3 ± 13.2 444.1 ± 17.4
6k m-NO2 700.8 ± 23.6 486.6 ± 18.5 520.7 ± 24.1
6l p-Cl 220.9 ± 11.2 517.0 ± 18.6 303.3 ± 8.5
6m p-F 171.9 ± 5.3 421.6 ± 15.4 231.2 ± 5.7
6n p-CH3 87.0 ± 4.0 288.3 ± 7.4 13.5 ± 3.0
6o p-OCH3 124.9 ± 5.9 718.4 ± 13.2 162.3 ± 5.2
6p p-NO2 789.2 ± 16.4 432.5 ± 10.3 336.6 ± 11.1
6q p-COOH 916.3 ± 15.5 522.0 ± 4.0 457.3 ± 10.7
FLC 15.6 ± 2.2 7.8 ± 1.5 8.5 ± 1.7