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. 2022 Apr 20;29(5):972–982. doi: 10.1038/s41418-022-00999-w

Fig. 5. Inhibition of key RNA helicases affects multiple cellular processes triggering p53.

Fig. 5

A. EIF4A3 has essential functional roles in the exon junction complex (EJC) and in ribosome biogenesis. Upon inhibition of EIF4A3 ribosome biogenesis is impaired, certain mRNA including MDM2 undergo alternative splicing and there is accumulation of R loops and DNA damage, insults converging on p53. B DDX21 supports RNA Pol I transcription to boost ribosome biogenesis. It also binds the 7SK RNP complex to aid RNA Pol II-mediated transcription of ribosomal protein (RP) genes and snoRNA. Upon inhibition of DDX21 ribosome biogenesis is impaired, R loops and DNA damage appear and p53 becomes activated.