Fig. 3. Differences in diverse mammalian proline domains.

a–d Mammalian proline domains relate to activity cycle and body parameters. a The human proline domain corresponding to amino acids 72–98 was aligned to mammal p53 proteins downloaded from the UniProt [29] with the BLASTp algorithm. The maximum score was retrieved and the distributions of these scores were plotted for diurnal, nocturnal, and “other” mammals’ activity cycles derived from the COMBINE dataset [39]. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001. b–d Alignment scores are plotted against the log10 of the adult mass in grams (b), the log10 of the adult body length in millimeters (c), and the log10 of the typical longevity in days derived from the COMBINE dataset [39].