Table 1.

The distribution of missense mutations in the proline domain, the DNA binding domain and the tetramerization domain.

P53 domain	Observed mutations within domain	Residues within domain	Observed mutations/residue
ADJACENT AMINO ACIDS 46–54	57	10	5.7
PROLINE	319	46	6.93
DNA-BINDING	70045	191	366.73
TETRAMERIZATION	1071	34	31.5

73,857 missense mutations in the Tp53 gene were analyzed from different cancers and the observed number of mutations in the proline domain, the DNA binding domain, and the tetramerization domain are presented, along with the number of amino acids in each domain and the observed mutation frequency per amino acid residue (the target size).