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. 2022 May 11;227(3):541–543.e11. doi: 10.1016/j.ajog.2022.05.015

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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Supplemental Figure 4 — Illustrative images of placentas infected by SARS-CoV-2 with or without transplacental transmission

Images from a pregnancy without (left) or with transplacental transmission (right) are shown. Panels (A), (B), and (C) depict CD163 immunostaining, HES stain, and SARS-CoV-2 N-protein immunostaining, respectively. An infected placenta with transplacental transmission shows a higher degree of chronic intervillositis as seen in HES stain with macrophage infiltration as demonstrated by CD163 immunostaining.

C, COVID-19; HES, hematoxylin-eosin-saffron; N-protein, nucleoprotein; P, placenta.

Vivanti. Transplacental SARS-CoV-2 transmission, placental inflammation, and fetal distress. Am J Obstet Gynecol 2022.