Supplemental Table 2.

Basic clinical details of pregnancies enrolled in the 3 groups

Variable	C+P− (n=10)	C+P+ (n=10)	C+P− vs C+P+: P value	Controls (n=11)	3-group comparison: overall P value
Age (y)	30.7 (3.8)	28.8 (2.9)	.308	33 (5.3)	.181
BMI	26.2 (5.5)	24.8 (4.8)	.621	24.2 (4.2)	.641
Preeclampsia	0 (0)	0 (0)	NA	1 (9.0)	.470
Gestational diabetes mellitus	1 (10.0)	3 (30.0)	.582	1 (9.0)	.349
IUGR	1 (10.0)	1 (10.0)	1	0 (0)	.279
Cesarean delivery	3 (30.0)	7 (70.0)	.179	4 (36.4)	.152
Gestational age at the delivery (wk)	33 (5.9)	33.4 (5.8)	.930	38.2 (4.6)	.07
Prematurity	6 (60.0)	6 (60.0)	1	2 (18.2)	.082
Newborn birthweight (g)	2003 (1151)	2039 (905)	.908	2784 (782)	.132
5-min Apgar score	10 (3.05–10.0)	10 (7.0–10.0)	.240	10 (10.0–10.0)	.485

C+/P− and C+/P+ indicate women affected by COVID-19 in the first trimester of pregnancy with negative (n=10) or positive (n=11) RT-PCR in placental tissue samples, respectively. Controls indicated healthy pregnant women (unaffected by COVID-19). BMI and Apgar score are dimensionless variables. Data are expressed as mean (standard deviation), median (interquartile range), or number (percentage), unless otherwise specified. Dichotomous data were analyzed using the chi-square or Fisher test, as appropriate. Continuous data were compared using the Student test (C+P− vs C+P+ comparisons) or with 1-way analysis of variance (3-group comparisons). P values are shown for the comparisons between C+P+ and C+P− groups and for the overall 3-group comparisons.

BMI, body mass index; C, COVID-19; IUGR, intrauterine growth restriction; NA, not available; P, placenta; RT-PCR, real-time polymerase chain reaction.

Vivanti. Transplacental SARS-CoV-2 transmission, placental inflammation, and fetal distress. Am J Obstet Gynecol 2022.