Table 1.
Sample descriptions and SNP-based heritabilities of 16 mental health traits.
| Phenotype (abbreviation) | PMID | Sample size (N) | SNP-based heritability | TWAS FUSION (N) | ||||
|---|---|---|---|---|---|---|---|---|
| Case | Control | Total | h2snp (se) | Z | Genes | Novel | ||
| Anorexia Nervosa (AN) | 28494655 | 16,992 | 55,525 | 72,517 | 0.429 (0.0282) | 15.21 | 74 | 20 |
| Attention Deficit Hyperactivity Disorder (ADHD) | 30478444 | 19,099 | 34,194 | 53,293 | 0.217 (0.0141) | 15.41 | 53 | 12 |
| Autism Spectrum Disorder (ASD) | 30804558 | 18,382 | 27,969 | 46,351 | 0.112 (0.0097) | 11.54 | 54 | 13 |
| Anxiety Disorders (ANX) | 26754954 | 31,977 | 82,114 | 114,019 | 0.125 (0.0090) | 13.92 | 42 | 41 |
| Bipolar Disorder (BIP) | 31043756 | 20,352 | 31,358 | 51,710 | 0.200 (0.0101) | 19.83 | 171 | 58 |
| Depression (DEP) | 30718901 | 246,363 | 561,190 | 807,553 | 0.073 (0.0025) | 29.00 | 185 | 37 |
| Obsessive Compulsive Disorder (OCD) | 28761083 | 2688 | 7037 | 9725 | 0.280 (0.0432) | 6.48 | 15 | 15 |
| Post Traumatic Stress Disorder (PTSD) | 31594949 | 23,212 | 151,447 | 174,659 | 0.053 (0.0095) | 5.53 | 18 | 13 |
| Schizophrenia (SCZ) | 29483656 | 40,675 | 64,643 | 105,318 | 0.234 (0.0083) | 28.17 | 597 | 112 |
| Tourette’s Syndrome (TS) | 30818990 | 4819 | 9488 | 14,307 | 0.213 (0.0248) | 8.59 | 27 | 15 |
| Drinks Per Week (DrnkWk) | 30643251 | – | – | 537,349 | 0.049 (0.0021) | 23.19 | 260 | 62 |
| Smoking Initiation (SmkInit) | 30643251 | 311,629 | 321,173 | 632,802 | 0.104 (0.0033) | 31.64 | 312 | 72 |
| Cigarettes Per Day (CigDay) | 30643251 | – | NA | 263,954 | 0.073 (0.0069) | 10.52 | 163 | 36 |
| Smoking Cessation (SmkCes) | 30643251 | 92,573 | 220,248 | 312,821 | 0.060 (0.0039) | 15.36 | 61 | 19 |
| Age of Smoking Initiation (AgeSmk) | 30643251 | – | – | 262,990 | 0.047 (0.0028) | 16.93 | 70 | 23 |
| Cannabis Use Initiation (CanInit) | 30150663 | 43,380 | 118,702 | 162,082 | 0.118 (0.0075) | 15.69 | 74 | 24 |