Table 3. Covariates-adjusted overall mortality HR based upon receipt of adjuvant chemotherapy.
| HRF | HR (95% CI) | P |
|---|---|---|
| T4 tumors | 0.566 (0.433–0.741) | <0.001 |
| Poorly/undifferentiated tumor | 0.468 (0.237–0.924) | 0.029 |
| Positive CEA | 0.669 (0.371–1.208) | 0.183 |
| Positive PNI | 0.421 (0.101–1.762) | 0.236 |
| TD | 1.146 (0.285–4.602) | 0.848 |
| <12 LN examined | 0.682 (0.376–1.238) | 0.208 |
| Unmarried status | 1.013 (0.745–1.377) | 0.933 |
| Mucin-producing tumors | 0.044 (0.001–689.559) | 0.526 |
| Left tumors | 0.831 (0.614–1.125) | 0.231 |
| T4 tumors + left tumors | 0.527 (0.337–0.826) | 0.005 |
| T4 tumors + unmarried status | 0.481 (0.325–0.710) | <0.001 |
| T4 tumors + positive CEA + left tumors | 0.418 (0.234–0.745) | 0.003 |
| T4 tumors + left tumors + unmarried | 0.547 (0.337–0.794) | 0.002 |
| T4 tumors + <12 LN examined + unmarried status | 0.265 (0.114–0.619) | 0.002 |
| Poorly/undifferentiated tumors + T4 tumors | 0.671 (0.382–0.879) | 0.030 |
| Poorly/undifferentiated tumors + unmarried status | 0.386 (0.171–0.873) | 0.022 |
HR, hazard ratio; HRF, high-risk factor; CI, confidence interval; CEA, carcinoembryonic antigen; PNI, perineural invasion; TD, tumor deposits; LN, lymph nodes.