Fig. 3.

Increased RV free wall thickness (RVFW) in SuHx group was restored by SFN in wild type mice but not in Nrf2 knockout mice. Reduced RV diastolic function (E/E’) and tricuspid annular systolic excursion with SuHx was attenuated by SFN in wild type mice but not in Nrf2 knockout mice. A1: RVFW, B1: E/E’ ratio. C1: TAPSE in wild type mice. D1: RV Tei Index. n = 4, 6, 6 for CTL (blue), SuHx (red), and SuHx+SFN (green) groups, respectively. A2: RVFW, B2: E/E’ ratio. C2: TAPSE in Nrf2 knockout mice. D1: RV Tei Index. n = 4, 4, 5 for CTL (blue), SuHx (red), and SuHx+SFN (green) groups, respectively. *P < 0.05, **P < 0.01, #P < 0.05, ##P < 0.01 between indicated groups at the same time point