TABLE 1.
Parameters | N (%) | Median (range) | Cut-off value RFS/OS | |
---|---|---|---|---|
Age (yrs) | 65 (38–80) | 62/66 | ||
<62 | 23 (34) | |||
≥62 | 44 (66) | |||
<66 | 35 (52) | |||
≥66 | 32 (48) | |||
Gender | ||||
male | 36 (54) | |||
female | 31 (46) | |||
Type of surgery used for metastasectomy | ||||
laparoscopy | 11 (16) | |||
open | 56 (84) | |||
Resection margin | ||||
R0 | 46 (69) | |||
R1 | 21 (31) | |||
Synchronicity of primary surgery and metastasectomy | ||||
synchronous | 7 (10) | |||
metachronous | 60 (90) | |||
Preoperative (metastasectomy) chemotherapy ± targeted therapy | ||||
none | 16 (24) | |||
yes | 51 (76) | |||
targeted | 43 (84) | |||
Postoperative (metastasectomy) chemotherapy ± targeted therapy | ||||
none | 18 (27) | |||
yes | 49 (73) | |||
targeted | 27 (55) | |||
Pre- or postoperative chemotherapy ± targeted therapy | ||||
none | 3 (4) | |||
yes | 64 (96) | |||
targeted | 48 (75) | |||
WBC (G/l) | 6.8 (3.5–12.5) | 6.8/7.1 | ||
<6.8 | 32 (48) | |||
≥6.8 | 35 (52) | |||
<7.1 | 35 (52) | |||
≥7.1 | 32 (48) | |||
neutrophil (G/l) | 4.3 (1.2–9.2) | 4/4.8 | ||
<4 | 27 (40) | |||
≥4 | 40 (60) | |||
<4.8 | 41 (61) | |||
≥4.8 | 26 (39) | |||
lymphocyte (G/l) | 2 (0.8–3.7) | 1.94/2 | ||
<1.94 | 32 (48) | |||
≥1.94 | 35 (52) | |||
<2 | 36 (54) | |||
≥2 | 31 (46) | |||
platelet (G/l) | 244 (105–446) | 210/184 | ||
<210 | 20 (30) | |||
≥210 | 47 (70) | |||
<184 | 10 (15) | |||
≥184 | 57 (85) | |||
NLR | 2 (0.7–8.8) | 2/1.7 | ||
<2 | 30 (45) | |||
≥2 | 37 (55) | |||
<1.7 | 18 (27) | |||
>1.7 | 49 (73) | |||
SII (G/l) | 502 (125–1952) | 535/290 | ||
<535 | 39 (58) | |||
≥535 | 28 (42) | |||
<290 | 9 (16) | |||
≥290 | 58 (84) | |||
GOT (U/l) | 25 (13–343) | 24/24 | ||
<24 | 22 (37) | |||
≥24 | 37 (63) | |||
NA | 8 | |||
GPT (U/l) | 22 (9–296) | 31/17 | ||
<31 | 48 (80) | |||
≥31 | 12 (20) | |||
<17 | 14 (23) | |||
≥17 | 46 (77) | |||
NA | 7 | |||
Site of progression | ||||
liver | 33 (63) | |||
lung | 5 (10) | |||
liver+lung | 7 (13) | |||
other | 7 (13) | |||
Extent of progression | ||||
single | 41 (61) | |||
multiple | 11 (16) | |||
none | 15 (22) |