TABLE 1.
Demographic statistics associated with Tier 1 status, notification status, and whether a participant had an EHR record. Comparisons of age, sex, and ethnicity were made for all Tier 1 conditions combined, and for HBOC, LS, and FH participants separately.
| N (%) | Age, Mean (SD)* | Female, n (%)** | White, n (%)** | Missing Demographic Data, n (%) | |
|---|---|---|---|---|---|
| HNP | 41835 (100.0%) | 51.7 (17.2) | 27836 (66.6%) | 33958 (81.3%) | 47 (0.1%) |
| All Tier 1 conditions | |||||
| HNP | |||||
| Tier 1 positive | 520 (1.2%) | 50.1 (17.2) | 343 (66.1%) | 429 (82.7%) | 1 (0.2%) |
| Tier 1 negative | 41315 (98.8%) | 51.7 (17.2) | 27493 (66.6%) | 33529 (81.2%) | 46 (0.1%) |
| p-values | 0.0458 | 0.8149 | 0.4287 | ||
| Tier 1 positive | |||||
| notified | 293 (56.3%) | 50.1 (17.7) | 194 (66.2%) | 261 (89.1%) | 0 (0.0%) |
| not notified | 227 (43.7%) | 50.1 (16.6) | 149 (65.9%) | 168 (74.3%) | 1 (0.4%) |
| p-values | 0.9025 | 1.0000 | 0.0000 † | ||
| Tier 1 positive + notified | |||||
| EHR | 250 (85.3%) | 50.5 (17.9) | 166 (66.4%) | 228 (91.2%) | 0 (0.0%) |
| no EHR | 43 (14.7%) | 47.5 (17.0) | 28 (65.1%) | 33 (76.7%) | 0 (0.0%) |
| p-values | 0.3294 | 0.863 | 0.0136 | ||
| Hereditary Breast and Ovarian Cancer Syndrome | |||||
| HNP | |||||
| HBOC positive | 268 (0.6%) | 49.1 (17.1) | 166 (62.2%) | 225 (84.3%) | 1 (0.4%) |
| HBOC negative | 41567 (99.4%) | 51.7 (17.2) | 27670 (66.6%) | 33733 (81.2%) | 46 (0.1%) |
| p-values | 0.0183 | 0.1342 | 0.2376 | ||
| HBOC positive | |||||
| notified | 166 (61.7%) | 49.0 (17.2) | 102 (61.4%) | 144 (86.7%) | 0 (0.0%) |
| not notified | 102 (37.9%) | 49.3 (17.0) | 64 (63.4%) | 81 (80.2%) | 1 (1.0%) |
| p-values | 0.7518 | 0.7955 | 0.1681 | ||
| HBOC positive + notified | |||||
| EHR | 137 (82.5%) | 50.0 (17.1) | 85 (62.0%) | 123 (89.8%) | 0 (0.0%) |
| no EHR | 29 (17.5%) | 44.1 (17.3) | 17 (58.6%) | 21 (72.4%) | 0 (0.0%) |
| p-values | 0.093 | 0.8341 | 0.0293 | ||
| Lynch Syndrome | |||||
| HNP | |||||
| LS positive | 102 (0.2%) | 52.1 (17.9) | 72 (70.6%) | 85 (83.3%) | 0 (0.0%) |
| LS negative | 41733 (99.8%) | 51.7 (17.2) | 27764 (66.6%) | 33873 (81.3%) | 47 (0.1%) |
| p-values | 0.8365 | 0.4619 | 0.7031 | ||
| LS positive | |||||
| notified | 57 (55.3%) | 51.6 (18.7) | 41 (71.9%) | 52 (91.2%) | 0 (0.0%) |
| not notified | 45 (43.7%) | 52.7 (17.0) | 31 (68.9%) | 33 (73.3%) | 0 (0.0%) |
| p-values | 0.8031 | 0.8278 | 0.0301 | ||
| LS positive + notified | |||||
| EHR | 49 (86.0%) | 51.2 (19.1) | 36 (73.5%) | 45 (91.8%) | 0 (0.0%) |
| no EHR | 8 (14.0%) | 54.1 (16.6) | 5 (62.5%) | 7 (87.5%) | 0 (0.0%) |
| p-values | 0.8094 | 0.6735 | 0.5446 | ||
| Familial Hypercholesterolemia | |||||
| HNP | |||||
| FH positive | 153 (0.4%) | 50.4 (16.9) | 106 (69.3%) | 121 (79.1%) | 0 (0.0%) |
| FH negative | 41682 (99.6%) | 51.7 (17.2) | 27730 (66.6%) | 33837 (81.3%) | 47 (0.1%) |
| p-values | 0.3932 | 0.5478 | 0.4686 | ||
| FH positive | |||||
| notified | 73 (47.4%) | 51.2 (18.1) | 52 (71.2%) | 67 (91.8%) | 0 (0.0%) |
| not notified | 80 (51.9%) | 49.7 (15.8) | 54 (67.5%) | 54 (67.5%) | 0 (0.0%) |
| p-values | 0.6323 | 0.726 | 0.0003 † | ||
| FH positive + notified | |||||
| EHR | 66 (90.4%) | 50.7 (18.6) | 46 (69.7%) | 61 (92.4%) | 0 (0.0%) |
| no EHR | 7 (9.6%) | 55.3 (11.5) | 6 (85.7%) | 6 (85.7%) | 0 (0.0%) |
| p-values | 0.4593 | 0.665 | 0.4663 | ||
*
Test of statistical difference was Wilcoxon Rank Sum Test.
**
Test of statistical difference was Fisher’s Exact Test.
†
Statistically significant after Bonferroni correction, p < 0.0014.