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. 2022 Jan 27;29(5):895–910. doi: 10.1038/s41418-022-00943-y

Fig. 2. The canonical ferroptosis pathway.

Fig. 2

There are three basic elements for ferroptosis: substrate of lipid peroxidation, executor of lipid peroxidation, and anti-ferroptosis system. Disruption of the equilibrium of these elements may lead to ferroptosis. Arrows indicate positive effects. Perpendicular bars indicate negative effects.

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