Fig. 4. The complexity of p53-mediated ferroptosis.

p53-mediated ferroptosis can be regulated in diverse ways, including A post-translational modifications; B single-nucleotide polymorphism; C non-coding RNAs; D small molecules, ROS, iron, nutrient, cytokine, waste, and light; and E other proteins. Currently, lots of drugs are demonstrated to affect p53-ferroptosis pathway in distinct disorders, including F tumors; G organ injuries; H degenerative diseases and ageing; and I malaria. Blue arrows indicate positive effects. Perpendicular bars indicate negative effects. For the full names of the regulators and drugs, please refer to the main context or Tables 1 and 2.