Table 3.
Multivariate analysis of the factors associated significantly with pCR on the univariate level.
| Variable | Group and HER2 | Group and Ki67 | Group and Histological grade | Group, HER2, Ki67, and Histological grade | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI ) | P-value | OR (95% CI ) | P-value | OR (95% CI ) | P-value | OR (95% CI ) | P-value | |
| Group | ||||||||
| Metformin | 2.690 (0.700 to 10.335) | 0.15 | 3.474 (0.570 to 21.17) | 0.177 | 1.807 (0.452 to 7.224) | 0.403 | 3.697 (0.445 to 30.690) | 0.226 |
| Control | 1 | 1 | 1 | 1 | ||||
| HER2 | ||||||||
| Positive | 3.917* (1.030 to 14.899) | 0.045 | 2.035 (0.349 to 11.872) | 0.239 | ||||
| Negative | 1 | 1 | ||||||
| Ki67 | ||||||||
| ≥ 20% | 7.634 (0.824 to 70.752) | 0.074 | 4.497 (0.423 to 47.753) | 0.117 | ||||
| < 20% | 1 | 1 | ||||||
| Histological grade | ||||||||
| Grade 3 | 6.195 **(1.591 to 24.123) | 0.009 | 6.905* (1.323 to 36.035) | 0.022 | ||||
| Grade 1&2 | 1 | 1 | ||||||
OR Odds Ratio, HER2 human epidermal growth factor receptor 2, Ki67 proliferation index.
*Significant as compared to the control group at P value ≤ 0.05, CI: 95% confidence interval.
** Significant as compared to the control group at P value ≤ 0.01, CI: 95% confidence interval.