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. 2022 May 10;13:2558. doi: 10.1038/s41467-022-30050-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Single base substitution (SBS) signature contribution in PCNSL and SCNSL. Stacked bar plots are ordered by subgroup and then decreasing mutations load (a). The left bar plot shows the number of SNVs and the right shows the normalized signature exposures. Each color corresponds to a mutations signature and the proportion of the color reflects the number or proportion of SNVs explained by a certain mutational signature. The heatmap shows the clustering pattern of the SBS mutational signatures in all CNSL and peripheral lymphomas (b), which revealed groupings mutational signatures SBS5, SBS9, and SBS40. Pairwise comparison of PCNSL with DLBCL or FL (Mann–Whitney U test) revealed that signature SBS1 was significantly enriched in PCNSL compared to DLBCL (p = 0.027; c). Box and whisker plots show median (center line), the upper and lower quartiles (the box), and the range of the data (the whiskers), excluding outliers. Small insertion and deletion (ID) signatures in CNSL and peripheral lymphoma (d) demonstrate elevated numbers of indels and mutational patterns associated with slippage during DNA replication of the replicated DNA strand (ID1) and template DNA strand (ID2) in PCNSL.